Late Cardiac Complications of Chronic, Severe, Refractory Anemia with Hemochromatosis

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Late Cardiac Complications of Chronic, Severe, Refractory Anemia with Hemochromatosis.

A MONG patients wlho from infancy have had severe anemia, refractory to therapy and usually reqtiiring transfuisions, xve have observed the development of one or 1)0th of txxo cardiac complicationis uinuisuial for anicmia alone." One, acute pericarditis, appeared benign but often recutrred, xxhereas the seconid, congestive lheart failuire and arrhythmias, led to death xithin a few montlhs to a ...

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Association of HLA-linked hemochromatosis with idiopathic refractory sideroblastic anemia.

Five of seven patients with idiopathic refractory sideroblastic anemia carried an HLA-A3 alloantigen (relative risk, 7.3; P = 0.02). The significance of this association was strengthened by study of two pedigrees. An abnormality in iron metabolism was found in two siblings who had an HLA-A3,B14 haplotype in common with the first proband. A second proband with idiopathic refractory sideroblastic...

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Cardiac enlargement in chronic severe anemia.

ALTHOUGH eardiae enlargement in patients with ehronie severe anemia was reported earlier in necropsy studies," 2 it was first demonstrated roentgenologically by Ball,3 who also showed that enlargement disappeared with correction of anemia. Enlargement has been attributed to dilatation or hypertrophy associated with dilatation.3 Experimentally Ludke and Schuller" demonstrated cardiac dilatation ...

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ژورنال

عنوان ژورنال: Circulation

سال: 1964

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.30.5.698